Evaluation of TH17 profile in common variable immunodeficiency patients with or without autoimmunity
نویسندگان
چکیده
Background Common Variable Immunodeficiency (CVID) is the most common symptomatic primary antibody deficiency in clinical practice and it is characterized by hypogammaglobulinemia, increased susceptibility to infections, autoimmune diseases and malignancies. The pathogenesis of CVID is still not well established. Immunologic abnormalities found in CVID patients include defects in B cell differentiation, in T cell function, altered receptor expression and cytokine production, regulatory cell disturbances and disorders of innate immunity. The aim of this study was to evaluate the TH17 profile of CVID patients, in order to observe if CVID patients with autoimmunity present a TH17 polarized cellular response pattern.
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